Nature Biotechnology, Published online: 19 August 2026; doi:10. 1038/s41587-026-03290-2 MOSAIC is a high-throughput gene synthesis method driven by hybridization (the self-assembly of complementary oligonucleotides during thermal annealing) instead of enzymatic processing.
ORIGINAL PAPER
Massive-scale parallel gene synthesis with oligonucleotide hybridization
WHAT WE KNOW
By using the full capacity of microchip-based oligonucleotide synthesis, MOSAIC enables the parallel production of over 1,000 distinct gene fragments and mutant libraries in a simple ‘one-pot’ reaction.
WATCH NEXT
Review the primary source, validate the main result, and establish whether any listed-company transmission is direct.
EVIDENCE
What the evidence supports so far
Research signals
synthetic-biology
What remains unverified
The full methodology, effect size, and limitations still require analyst review.
Company impact remains unverified until a direct economic transmission is established.